As macrophages are majorities of the immune cells, they possess important biological functions in the initiation, maintenance and resolution of inflammation. The pivotal event of inflammatory response in the colon is the activation of colonic macrophages. Therefore, it is paramount to explore innovative therapies and potential medications for IBD. Although these existing therapeutic options are effective in treating IBD clinically, they have consequential limitations such as side effects, tolerance of patients, and high medical cost of drugs. In clinics, the current treatment for IBD includes 5-aminosalicylic acid (5-ASA), corticosteroids, immunosuppressant agents, biological therapies and antibiotic therapies. Although the etiology of IBD is not fully understood, genetic determinants, deregulation of the mucosal immune system, dysbiosis of gut microbiota and environmental factors were exhibited to be essential factors in the development of IBD. Epidemiological studies show the incidence of IBD has been popular in western countries and it is continuing to rise in developing nations due to the western diet and lifestyle, bringing a substantial burden to patients, health care system and society worldwide. Inflammatory bowel disease (IBD) is a chronic inflammatory condition of intestinal mucosa, which includes Crohn’s disease (CD) and ulcerative colitis (UC). These results suggest uvaol is a prospective anti-inflammatory agent for colonic inflammation. venetum leaf contains uvaol and uvaol has potent anti-inflammatory effects on DSS-induced experimental colitis and LPS-stimulated RAW264.7 macrophage cells. Mechanically, uvaol inhibits the pro-inflammatory ERK/STAT3 axis in both inflamed colonic tissues and macrophages. Studies on LPS challenged murine macrophage RAW246.7 cells also revealed that uvaol reduces mRNA expression and production of pro-inflammatory cytokines and mediators. Moreover, uvaol significantly reduces mRNA expression and production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, and MCP-1) and infiltration of macrophages in colonic tissues of colitis mice. We further found uvaol could attenuate disease activity index (DAI), colon shortening, colon injury, and colonic myeloperoxidase activity in DSS-induced colitis mice. leaf and found uvaol has excellent potential of inhibiting NO production. We isolated uvaol from ethanol extract of A. The disease activity index was determined by scores of body weight loss, diarrhea and rectal bleeding histological damage was analyzed by H&E staining macrophages change in the colon were analyzed by immunohistochemistry (IHC) myeloperoxidase activity was measured by myeloperoxidase assay kits levels of proinflammatory cytokines were determined by qPCR and ELISA protein production such as COX-2, iNOS, STAT3 and ERK1/2 were determined by western blotting. We investigated anti-Inflammatory effects on dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide (LPS)-stimulated RAW264.7 cells. leaf and detected the most effective compound by NO inhibition assay. We isolated compounds from ethanol extract of A. venetum L., we did a phytochemistry study and investigated anti-Inflammatory effects of compounds and explored the underlying mechanisms. To understand the bioactive constituents of A. Apocynum venetum leaves are used as a kind of phytomedicine and the main ingredient in some traditional Chinese medicine products for the relief of colitis.
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Leo Bennett (Joe Holt) is said to be away seeking a cure for the zombie plague for the Civic Republic. Now I was 99% sure that he was lying due to the fact that he was tryna hide it in the trash but then I have to think "why is he dumping medicine that he could need later on down the road" and if he really does have a sick sister and she doesn't get the medicine because of what I've done, then what happens to her is essentially my fault and I don't exactly want something like that to be stuck in my mind. Over on spin-off The Walking Dead: World Beyond, renowned biochemist and geneticist Dr. I didn't rob from him - Even in an apocalypse I feel it isn't right to steal from anyone, plus I was thinking more long term and after learning that he was part of a group (through the dialogue choice I chose) I didn't want to risk them coming after our group and giving them a reason to try and kill us because I robbed them, especially with a baby on the way (only to find out that they come back no matter what).Įdit: something which just came to mind is that he said that the medicine was for his sister. Nicki Rapp, Voice of Lilly AMA on r/TeamLilly.Gavin Hammon, Voice of Kenny AMA on r/TeamKenny.Melissa Hutchison, Voice of Clementine (AMA #2).Ian Howe (Skybound Games) and Kent Mudle (Creative Director for The Final Season).
So, while you are downloading and trying out time synchronization, it’s time for me to open that bottle of Laphroaig Select waiting on my coffee table. Kuuvik Capture is a tethered shooting software for Mac that provides you with. My book, Kuuvik Capture Inside Out, was also updated to reflect the new features. Kuuvik Capture has many unique features that help you to get the job done quickly, with fantastic results. New users can purchase the app from the Mac App Store. Version 3.1 is a free update for existing Kuuvik Capture 2.x and 3.0 users. The complete list of new features, changes and fixes is available in the release notes. The synchronization process also sets the daylight saving time flag, so there’s no need to fiddle with your cameras at the beginning and the end of daylight savings periods – just connect them to Kuuvik Capture. If you were fed up with Canon’s awkward time zone naming (the same city name could refer to different time zones on different cameras), this is a remedy. Laszlo's eBook on the ins and outs of Kuuvik Capture is available now Jump to. Synchronize date/time with the Mac will set the date, the time, and the time zone (on cameras that can handle it) of the camera to match your Mac’s each time a connection to Kuuvik Capture is made. By DIRE Studio 4.99 Visit Site Developers Description By DIRE Studio The original and only Mac shutter count reader that works with all new Canons ShutterCount displays the number of. This is needed to fit it on smaller screens (such as the 12″ MacBook).Īnd the app has a new function, with an accompanying preference. The Preferences window is now tabbed to make it smaller vertically. Along the usual addition of new cameras (the 77D / 9000D and 800D / Rebel T7i / Kiss X9i this time), this version brings support for movie recording on the 6D and 80D, and extends multi-point live view support to the 80D.īut there’s one more thing. Version 3.1 of my Kuuvik Capture tethering app is available on the Mac App Store. When it comes to pricing, Parallels offers both a yearly subscription and a one-time purchase option. Naturally this will change depending on your internet connection speed and hardware configuration, but it’s impressive all the same. While convenient, this raises security concerns, however, so additional protection (like using an antivirus software on Windows is recommended).Īfter picking the first solution offered by Parallels that includes a legitimate copy of Windows 10 from Microsoft, the whole installation process – meaning both Parallels and the download of Windows 10 – took less than 40 minutes. Its location will remain unchanged even after editing unless you move it. In other words, you won't have to manually drag and drop a Corel Draw file you received via email just save it to a shared folder, launch the respective app in Windows, and start editing the image. This combined with shared cloud folders streamlines workflow, especially since it means another neat feature of Parallels – drag and drop – is no longer necessary to share data between the two operating systems. By default, Parallels Desktop provides something they call a “Shared Profile”, which shares the user's home folder with Windows. When it comes to sharing, virtual machines are a relief because they make possible what is impossible via Boot Camp: sharing folders and files between systems. Simply put, Parallels Desktop won’t put too much strain on modern hardware. Data transfer times are just as snappy, too, for example a 4.7 GB file from macOS to Windows 10 and vice-versa took only 30 seconds to copy over via USB-C. Meanwhile, directly clicking on a Windows-only file on the Mac system will speed up boot time to just 20 seconds, while it takes only 10 seconds if Parallels was already open. We tested the program on a MacBook Pro (late 2016) and the boot times of Parallels for Mac performed quite well, taking only 27 seconds to launch both Parallels and Windows 10. Virtual machines can be configured so that they start automatically alongside macOS or whenever Parallels Desktop is launched. Windows 10 under Parallels also supports the macOS function Quick Look, which is very helpful indeed. Travel Mode, for example, will prolong battery life unless you start playing games on the Windows platform, the latter of which is possible thanks to in-built DirectX support. Launching Parallels Desktop will have a noticeable impact on the Mac's performance since it is sharing the computer’s limited resources with a whole other operating system at the same time, however the developers have done a terrific job of optimizing the software's performance to lower the energy and resource impact that it has on the system. It’s very convenient to be able to get started using Windows 10 without an install disk or to transfer apps and files from an older PC using the Parallels Transfer app. But the main reason regular users might install Parallels or its competitors is for standard Windows. Parallels Desktop provides a variety of free systems, covering the likes of a Windows 10 Development environment, a Modern IE environment, a handful of Linux operating systems (with the key ones being Ubuntu, Fedora, and Debian/GNU), Android and even macOS 10.13.4 from the Recovery Partition. Using a virtual machine allows the whole disk formatting step to be skipped and instead proceed with directly installing the desired operating system. It does so by delivering virtual desktops and applications to any device, running Windows on a Mac, Mac management with Microsoft System Center Configuration Manager (SCCM), remote access to PC and Mac computers from any device, as well as simplifying common computing tasks on both PC and Mac computers. The company behind Parallels Desktop is Washington-based Parallels Inc., creators of cross-platform software enabling businesses and individuals to use their favorite devices and technology on any number of platforms, covering everything from Windows, Mac and mobile to Linux, Raspberry Pi or the cloud. In addition to the 14-day trial, a Parallels purchase is protected by the company’s 30-day money-back guarantee. All that for as low as $6.66 per month, which includes a handy toolset and remote access to the computer desktop. Alongside eliminating the need to reboot into the desired operating system, it's also speedy enough to launch, suspend, and resume Windows and its apps without ever interfering with your activities. If your time is shared almost equally between macOS and Windows, then Parallels Desktop 13 is a welcome addition to your workflow. Less user-friendly storage optimization.Duplicate task bar icons in the menu bar. The US CPSC is currently working with eCommerce sites to regulate and remove any online listings for batteries unsafe for consumer sale. However, there's been a rise in reports of loose 18650 batteries being sold online on sites like Amazon or eBay. They shouldn't be available for use or individual resale to consumers. The report states that li-ion batteries should be used only as a single component of a battery pack. Unsafe And Exploding Batteries?Īlthough proper battery usage in your vape will not likely result in any accidents or injuries, it certainly is possible.Įarlier this year, the United States Consumer Product Safety Commission issued a warning against buying or using loose 18650 li-ion batteries due to a disturbing trend in improper usage and personal injury. Most often, these incidents were the result of improper usage or storage conditions. In recent years, there's been a growing trend in accidents happening with these types of batteries. Most branded lithium-ion batteries will have a label indicating their voltage, size, and mAh rating. You'll find these batteries in all sorts of portable electronic devices, including power tools, mobile computers, digital cameras, electric vehicles, and, more importantly, in many vaping devices. Their name comes from their size, roughly 18mm in diameter and 65mm in length. In fact, over the years, there has been an increasing number of reports of personal injuries, burns, and explosions happening with these types of mobile power sources.īelow, we're looking at these lithium-ion batteries, often used in vape devices, and how to keep yourself safe when using or storing them! What Are 18650 Batteries?ġ8650 batteries are very versatile lithium-ion batteries, capable of providing long-lasting mobile battery power. However, like many things in life, when lithium-ion batteries are misused or mishandled, they can be dangerous. Rather than needing to keep devices, appliances, or cars plugged into a hard-wired power source, batteries allow us to be more mobile, bringing our devices with us on the go! There's no doubting the fact that lithium-ion batteries have been a handy invention of humankind. Have you heard about the dangers of 18650 batteries and how you should be careful when buying them online? In the following article, we explore 18650 battery safety, including adequately storing and using 18650 batteries. Now please hold my beer while I head over to the HeidiSQL forum to deliver a similar speech. Wine 6.0.1 is a maintenance release, but the ability to run 64 bit Windows apps on MacOS Big Sur for M1 Macs (along with more than 60 other bugfixes) is a bit of a big deal, as it doesn’t support. So with a good conversion and reasonable pricing, it should be possible to finance the work, and maybe an extra Starbucks once in a while? I know I’d buy it immediately out of my own pocket if it was avaiable, and I can’t be alone. Also probably 32 bit apps will be supported by a normal free version of wine at some point. And after reading the “poop factory” sentiment from another (legendary) post, I can see why a partnership with a commercial development studio is not desirable.īut maybe there are other options, like involving other independent developers? Nobody likes working for free, but luckily Apple fanbois are used to paying for everything, all the way down to ringtones for their phones. Download Wine 5.0 / 5. You can download the trial version for free and test it for free for 14 days. GeNIe can be used on a Mac with Boot Camp (available only on Intel-based Macs, boots the computer into Windows. My colleagues look at me like I am from another planet when I trashtalk their Atom, vCode, textMate, brackets, bbedit etc, but they just can’t get the job done as efficiently as I can with notepad++.Īs Notepad++ is heavily reliant on Win32, I can understand what kind of undertaking it would be to rebuild it from the ground up. Free Download for Mac Softonic review Run Windows apps on your Mac OS Wine is an open-source software program that helps in running Windows applications on Mac computers. ago No need to download these manually brew has already upgraded there casks to serve the provided packages. However these are WIP builds so don't expect them to be fully stable. Unlike the original Wineskin Project by doh123 that worked on OS X 10.6 to macOS 10. You can download the portable version of both Wine 7.0 and 7.1 at under releases. After being disappointed with at least 10 different, promising native editors, I got notepad++ up and running somewhat acceptable, but not great. Download the desired package from releases unpack, now move the Wine bundle to /Applications and use as you would a Winehq. Wineskin is a user-friendly tool used to make ports of Microsoft Windows software to macOS. IT dept recently forced a m1 macbook on me, as I was the last one clinging to my trusty (but old) windows laptop. The Burma-Siam Railway was 250 miles of railway constructed by Allied prisoners of war alongside forced Asian labourers. It’s this structure, Bridge 277, that still stands and is a famous local tourist attraction.īut, what about the real men behind the real story of the construction of the Burma-Siam Railway? Let’s examine the history behind the film and the men who made it. In fact, there were two: one a wooden railway bridge and the other a ferroconcrete structure built using imported bridge sections from Japanese-controlled Java. The bridge depicted in the film is most definitely real. For many, it’s their first exposure to the horrors prisoners of wars suffered in the Far East. Since it first graced the silver screen won the admiration of audiences everywhere and continues to do so. It was the highest-grossing film of 1957 and scooped up seven Academy Awards, including Best Film, Best Director, and Best Actor. The Bridge on the River Kwai was a smash hit on release. Boulle drew on the experiences of Far East POWs building the now infamous Burma-Siam Railway, linking modern-day Myanmar and Thailand to create his work. The film was based on the 1952 novel Bridge over the River Kwai by Pierre Boulle. Starring Alec Guinness, it depicts the struggles and defiance of Japanese prisoners of war building the fictional Burma railway between 1943-44. Image: The iconic poster of the 1957 classicĭavid Lean’s 1957 epic Bridge on the River Kwai is regarded as one of the all-time great war films. If the corn isn't there yet, cook it a little longer. You’re ultimately aiming for hot, juicy kernels that burst under the pressure of your teeth. (If the corn is in its husk, protect your hands with mitts or gloves and carefully peel back a segment of the husk). To check on doneness, get a look at the kernels, which will be a brighter yellow if it’s yellow corn, or have less of a pearly look if it’s white corn. You can cook the corn longer if needed, but you can’t uncook corn. But the exact time depends on the method. How long to cook corn on the cobĬooking corn on the cob in a microwave or Instant Pot takes 3-4 minutes, boiling it on the stove takes 5-7 minutes, and roasting can take 25-40 minutes. Better yet, do what my dad does: wear a pair of heavy-duty work or gardening gloves dedicated specifically for that purpose. To remove the husks and silks from steaming-hot corn, protect your hand with a potholder, dry towel, or oven mitt. A drawback? Shucking hot corn can be tricky. A plus of cooking in the husk is how easily the silks come off after the corn is cooked. Husks on or off?ĭepending on the cooking method, you can cook corn on the cub with husks or without. Don’t do it! Leave the corn husks on until right before you cook to keep the sugars intact and kernels plump. Lots of produce sections set out trash cans for convenient in-store shucking. The husks should be pliable and green, not brittle. Fresh corn has silky tassels that are supple. If you can’t get freshly harvested corn, try a store or market you know has a high turnover. Which is basically once a week during sweet corn season, from July to early September. It’s plump and sweet and I feel totally lucky every time I buy a dozen or two ears. I may be hours away from the nearest Target and Trader Joe’s, but the rural area I live in has farm stands that sell corn harvested that very day. Once corn is picked, its sugars begin converting to starches, leading to tough corn. Note: Meal Planner is available only to Yummly paid subscribers. How to cook corn on the cob in the oven > How to cook corn on the cob on the stove > How to cook corn on the cob in an Instant Pot > How to cook corn on the cob in the microwave > Here’s the lowdown on the four handiest of the many ways to cook corn. (You want to grill corn? We’ve got a whole article just for you.) Want quickie corn on the cob for two? Look to your microwave. Grilling steaks with no room for corn? Then boil, roast, or pressure cook it. After that, just use the cooking method that’s most convenient. The best corn on the cob starts with the freshest corn possible. I easily eat three ears in a sitting, if it’s good. While corn might be a side dish for some, for me it’s the main event. Since moving back to Ohio, I’ve savored dozens of ears of corn prepared every which way. I’ve lived all over the U.S., including on both coasts, and I can confidently state no one knows or loves sweet corn more than the folks in the middle. Featured corn photographs by Brittany ConerlyĬorn is serious business where I’m from. Since your visibility changes when you're standing or crouching, even tasks like hiding a body have to be thought through to ensure you're in nobody's line of sight.ĭesperados III isn't a walk in the park. Characters like Doc or Kate can barely drag a body while in a hunched state, Cooper carries them standing up with no issue, and the bulky Hector can carry two at once. It adds a tactical layer that is fun to mess with.Ī character's physique also determines how well they can move deceased enemies to hide them. For example, she can link two enemies and have them share the same fate when you hurt or kill either one of them. While I can see people being slightly irritated by the inclusion of supernatural abilities, it opens up the gameplay in a fun way. Doc McCoy is an actual doctor and a capable sniper, and later in the game, we meet a new character, Isabelle Moreau, who's skilled in voodoo practices. Hector can whistle to lure enemies into a bear trap, and he has a shotgun to take out several enemies at once. Cooper dual-wields revolvers, has a throwing knife, and can use his coin to distract enemies or startle animals. She can also use disguises or flirt with enemies to lure them away from their post. Kate O'Hara cannot stealth kill enemies, but she can knock them out. The way you tackle missions depends greatly on who is in your party, since characters have specific strengths and weaknesses. Sometimes, you start alone and need to meet up with other characters at a specific spot, and other times, you start with a small group. Your group grows to a maximum size of five, but the game decides who you control in a given level. The characters are also part of the puzzle. Terrain and enemy positions are usually well thought out, so we need to carefully avoid or take out key characters to create openings for our group to slip by - or kill them all, if that's your prerogative. The mission maps usually have a few features, and enemies are everywhere, making each encounter feel like a puzzle. Your characters are dropped onto the map and given a handful of objectives to complete. View cones, safe zones, and restricted areas are always clearly marked. It's not necessarily about realism but about adhering to the game's rules to stay undetected while solving the puzzle. The order of the day is stealth, which works similar to the recent Hitman reboots but with more difficulty. While it includes a few frantic shootouts on the dusty streets of typical western scenery, your weapon of choice is usually anything but a firearm. Desperados is a tactical stealth game where, from an isometric perspective, we guide a group of characters to complete objectives on expansive maps. The undisputed star is the level design and gameplay, which thoroughly impressed me at Gamescom 2018. We still have a bird's eye view of a sprawling map and can command one or several of the characters to kill, sneak by or sabotage the environment to achieve a goal. All of the characters you encounter are stereotypical, but they have unique personality traits that are also reflected in the gameplay, which hasn't changed much over the years. From that perspective, it works incredibly well, and short cut scenes moved the story along at a decent pace. The story often felt like a means to an end, since it throws your characters into a lot of overwhelming situations and then you need to dig yourself out. The story is bare bones and slightly cheesy, but it remains engaging throughout, and the latter half has some interesting moments. In case you were concerned, you won't need any background in the series before jumping in. While I would've loved to see an actual sequel, a prequel makes a lot of sense, since the last entry was released more than 14 years ago. If you're as eager as me to see whether the team captured or surpassed the quality of Desperados, fret not, because Desperados III turned out better than I could have hoped on the consoles, including the PS4 version that we're reviewing today.ĭesperados III tells a prequel story about how gunslinger John Cooper met key characters of the cast, and the title eventually leads up to the first two entries. Here we are, as if my prayers were heard, with another main entry in the Desperados series courtesy of Mimimi and THQ Nordic. If you had asked me a few years ago about the game or genre that I miss the most in today's gaming landscape, my answer would've surely entailed a remake or sequel to either Commandos or Desperados - or any other game that marries stealth and isometric real-time strategy. “Involving the community in the development process is one of the main reasons we decided to go with Early Access. How are you planning on involving the Community in your development process? We may change the price after Early Access, but that’s 1-2 years out.” Will the game be priced differently during and after Early Access? An automator that allows you to automate complex skill combos and item purchases.” Three world types with unique environments, monsters, and world bosses. One hero with an expansive skill tree with over 600+ nodes to unlock. What is the current state of the Early Access version? We also plan to add many more features based on community feedback.” “The full version will have at least 3 heroes all with their own unique play styles, skills, and skill trees and also feature at least 2 more world types with special monsters and world bosses. How is the full version planned to differ from the Early Access version? We want at least 3 heroes and several more features before we are happy calling the game full version - “1.0”.”Īpproximately how long will this game be in Early Access? The app initially included 180,000 episodes from over 3,000 TV and Web shows, as well as 5,000 movies.“We chose Early Access because the game is playable but incomplete, and we want to involve the community in our development decisions before finalizing the game. The Clicker app does not include all of the content that currently is available on the website. On December 3, 2009, Clicker launched an application on Boxee, which allows users to watch Clicker content from their television. Content Ĭlicker's database included more than 750,000 episodes, from over 12,000 broadcast quality shows, from over 2,500 networks, 30,000 movies, and 90,000 music videos from 20,000 artists. Since Clicker has ceased to operate, other services have launched that perform a similar function, such as Movie Monitor. Īs of now, Clicker re-directs to with no previous Clicker functionality present. ĬBS Interactive acquired Clicker in 2011. The Clicker product received a large number of positive critical reviews, including The Wall Street Journal and CNET. The website was in private beta for two months, and then launched publicly two months later at Gigaom's NewTeeVee Live in San Francisco. Clicker was runner-up for the Audience Award at the show. The company was in stealth mode until it debuted at TechCrunch 50 (September 2009), with the stated goal of becoming the equivalent of TV Guide for the Web. As part of its Series A round, Clicker also integrated, an online video directory. Clicker's CEO is Jim Lanzone, former CEO of Ask.com. Board members include Bill Gurley of Benchmark, Geoff Yang of Redpoint, and Slingbox founder Blake Krikorian. History Ĭlicker received an $8 million Series A investment in October 2008 from investors Benchmark Capital and Redpoint Ventures, and an $11 million Series B investment in February 2010 from Jafco Ventures, Benchmark and Redpoint. Clicker also has mobile apps for the iPhone and Android devices which let users check-in to share what they're watching, find programming to watch on their phone, and manage their Playlist. Users who visit the site from their iPad will be automatically redirected to a special version of Clicker that provides a complete programming guide for the iPad, making it easy for iPad users to find what broadcast-quality programming is available to watch and what's not. In April, Clicker launched its iPad Edition. In July 2010, Clicker launched Clicker Social, which brought social discovery to the online television guide and let users share what they were watching, follow their friends, recommend shows and movies, and earn awards from content partners like HBO, PBS, Showtime, Crackle, Revision3, Snag Films, NCAA Vault and more. Additionally, Clicker offered many social features for sharing programming information on Facebook pages and Twitter. In addition to search and directory services, Clicker offered DVR-like features that enabled users to subscribe to shows and track when programs became available online. Clicker also began indexing Comcast Xfinity, Comcast's online library of TV shows and movies, in August 2010. While much of the streaming video content Clicker indexes was available for free, Clicker also pointed to paid services like Amazon Video-on-Demand, iTunes and Netflix Watch Instantly. It did not host any content, instead focusing on helping users discover and navigate to professional content hosted by rights-holders. It is owned by CBS Interactive.Ĭlicker indexed only legal video that is streamable online. Their website aimed to be the TV Guide for all full episodes of programs available to watch on the Web. Internet video directory and search company OwnerĬlicker was an Internet video directory and search company based in Los Angeles, California. |